TOT-DB, The Theileria Orientalis Genome Annotation Database
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The Theileria orientalis Genome Annotation Database [TOT-DB]

Theileria parasites are intracellular protozoans which are transmitted by ticks and cause economically important diseases in livestock including cattle, sheep and horses. There are several species with different range of pathogenicity from highly mortal, benign to non-pathogenic. Theileria orientalis, which is generally categorized into benign Theileria, mainly parasitizes in red blood cells and causes anemic disease in cattle. The parasite still can kill animals sometime if animals have secondary or mixed infections with viral and/or bacterial pathogens, or exposed under severe stressful conditions such as poor grazing conditions, long distance transport, pregnancy and delivery. Therefore, this parasite causes great economic damages in grazing cattle in Japan, Korea and North-east China. Recently, several severe clinical cases including deaths are reported in Australia and New Zealand.

In contrast, highly pathogenic species in the genus, T. parva and T. annulata parasitize primarily in lymphocytes and induce their transformation and immortalization leading infected animals to acute death. Intracellular protozoan parasites such as malaria parasites and Toxoplasma interact host cell molecules and modulate cellular functions. In particular, cancer-like growth of lymphocytes infected with malignant Theileria parasites is a very unique cellular event and has been attracting interests of cell biologists. The genomes of T. parva and T. annulata were sequenced and published in 2005.

In this project, we have sequenced the whole genome of T. orientalis by a whole genome shotgun sequence method combined with the manual gap closing followed by automated/manual annotation. The main purpose of the project is comparative genome analysis between highly pathogenic species, T. parva and T. annulata, and non-transforming Theileria species represented by T. orientalis.Genome-wide comparison of the parasites illustrates genetic background accounting for the unique biological effects associated with intracellular parasitism of Theileria. The ultimate goal is to impact on the control of theilerioses by generating a fully annotated whole genome sequence for Theileria.

Theileria orientalis genome browser (G-integra)

Theileria Orientalis
Theileria Orientalis

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